Pancreatic response after treatment with 1,5-Bis(3,5- dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in rats

摘要

3,5-Dimethylpyrazole (U-6245) is a hypoglycemic and antilipolytic agent used in the treatment of diabetes mellitus. Complex 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper was prepared in 2009. This study indicated that 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3- oxapentane-diacetatocopper has hypoglycemic properties by decreasing glucose level in blood but caused histopathological changes in the pancreas rats. Rats treated with 1,5-Bis(3,5-dimethylpyrazol-1- yl)-3-oxapentane diacetatocopper for 2, 4 and 6 weeks revealed inflammatory infiltration in the pancreas, marked cytoplasmic vacuoles, congestion of blood vessels with edema and haemorrhage, as well as, some of the degenerated cells showed necrosis. Large spaces were detected in some areas due to degeneration of cells. Sera of animals treated with 1,5-Bis(3,5-dimethylpyrazol-1-yl)-3-oxapentane diacetatocopper in the present study revealed a significant decrease in serum glucose after 2, 4 and 6 weeks of treatment.