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PREPARATION METHOD FOR 1-PHENYL-2,6-BIS(2-HYDROXYETHYL)IMIDAZO1,5-CQUINAZOLINE-3,5-DIONE AND 1-PHENYL-2,6-BIS(2-HYDROXYPROPYL)IMIDAZO1,5-CQUINAZOLINE-3,5-DIONE
PREPARATION METHOD FOR 1-PHENYL-2,6-BIS(2-HYDROXYETHYL)IMIDAZO1,5-CQUINAZOLINE-3,5-DIONE AND 1-PHENYL-2,6-BIS(2-HYDROXYPROPYL)IMIDAZO1,5-CQUINAZOLINE-3,5-DIONE
This method relates to the preparation of the compound of structural formula 1, where R is a hydrogen atom -H or methyl group -CH3 respectively, in reactions of 1-phenyl-2H,6H-imidazo[1,5-c]quinazoline-3,5-dione with formula 2 and oxiranes with formula 3 in form of ethylene oxide for R = -H or propylene oxide for R = CH3 respectively. In the first stage, reactions are conducted in pressurized reactor, at a molar ratio of 1-phenyl-2H,6H-imidazo[1,5-c]quinazoline-3,5-dione to oxirane equal to 1 :2, in solvent and in presence of triethylamine as catalyst, and in the second stage after the reaction is finished, catalyst and solvent are distilled off under reduced pressure, precipitated with acetone, and then the resulting compound is filtered and crystallized from ethanol. In the first step, in the case of ethylene oxide reactions are conducted at temperature of 60 ÷ 70 °C for at least 70 hours, whereas in the case of propylene oxide it is conducted at temperature of 70 ÷ 90°C for at least 90 hours. Furthermore, in the first step dimethyl sulfoxide is used as a solvent in the first step, whereas in the second step distillation of the catalyst and solvent is conducted under pressure lower than 10 mm Hg. The invention may be used as compounds having potential biological activity, starting compounds in synthesis of medicines or substrates for synthesis of other organic compounds with imidazoquinazoline ring.
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