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Method for producing 1-phenyl-2-(2-hydroxyethyl)-6H-imidazo1,5-cquinazolino-3,5-dione and 1-phenyl-2-(2-hydroxyethyl)-6H-imidazo1,5-cquinazolino-3,5-dione
Method for producing 1-phenyl-2-(2-hydroxyethyl)-6H-imidazo1,5-cquinazolino-3,5-dione and 1-phenyl-2-(2-hydroxyethyl)-6H-imidazo1,5-cquinazolino-3,5-dione
This refers to the formation of a compound with a structural formula 1, where R respectively means a hydrogen-H atom or a methyl-CH3 group, in reaction 1-phenyl-2H,6H-imidazo[1,5-c]quinazolino-3,5-dione with oxides of ethylene oxide for R =-H or propylene oxide for R =-CH3. In the first stage, reactions are carried out in a pressure reactor with 1-phenyl-2H,6H-imidazo[1,5-c]quinazolino-3,5-dione molar ratio to 1:1 oxirane, in the presence of triethylamine as a catalyst, the catalyst and solvent are distilled under reduced pressure at the second stage after completion of the reaction and the acetone-precipitating compound obtained,drains and then crystallises from ethanol. In the first stage, in the case of ethylene oxide, the reaction shall be carried out at temperatures 60 to 70'c for at least 70 hours, and in the case of propylene oxide at temperatures 70 to 90'c for at least 78 hours. In addition, dimethyl sulphoxide is used as a solvent in the first stage and in the second stage, the catalyst and solvent are distilled under pressure of less than 10 mm Hg. Application: as a potential biological agent,parent compounds in the synthesis of medicinal products, or substrates for the synthesis of other organic compounds with imidazochinasoline ring.
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