Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity

Jessica Chacon; Shari Pilon-Thomas; Amod Sarnaik; Patrick Hwu; Laszlo Radvanyi

首页> 外文期刊>Journal for ImmunoTherapy of Cancer >Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity

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Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity

机译：在黑色素瘤肿瘤扩散肿瘤浸润淋巴细胞（TIL）的起始过程中立即触发4-1BB共刺激会加速CD8 + T细胞的生长和肿瘤特异性

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《Journal for ImmunoTherapy of Cancer》 |2013年第s1期|共页
作者
Jessica Chacon; Shari Pilon-Thomas; Amod Sarnaik; Patrick Hwu; Laszlo Radvanyi;
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中图分类肿瘤学;
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1. Triggering co-stimulation directly in melanoma tumor fragments drives CD8(+) tumor-infiltrating lymphocyte expansion with improved effector-memory properties. [J] . Jessica Ann Chacon, Amod A Sarnaik, Shari Pilon-Thomas, Oncoimmunology. . 2015,第12期

机译：直接触发黑色素瘤肿瘤片段中的共刺激驱动CD8（+）肿瘤浸润的淋巴细胞扩张，具有改善的效应记忆特性。
2. CD40-ligated dendritic cells effectively expand melanoma-specific CD8+ CTLs and CD4+ IFN-gamma-producing T cells from tumor-infiltrating lymphocytes. [J] . Terheyden P, Straten P, Brocker EB, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2000,第12期

机译：连接CD40的树突状细胞可有效地从肿瘤浸润淋巴细胞中扩增黑色素瘤特异性CD8 + CTL和CD4 +IFN-γ产生性T细胞。
3. CD40-Ligated Dendritic Cells Effectively Expand Melanoma-Specific CD8+ CTLs and CD4+ IFN-γ-Producing T Cells from Tumor-Infiltrating Lymphocytes [J] . Patrick Terheyden, Per thor Straten, Eva-B. Br?cker, The journal of immunology . 2000,第12期

机译：CD40连接的树突状细胞可有效地从肿瘤浸润性淋巴细胞扩增黑色素瘤特异的CD8 + CTL和产生CD4 +IFN-γ的T细胞。
4. Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in tumors [C] . Kim Byung-Sam 2012 7th International Forum on Strategic Technology. . 2012

机译：施用6-姜油酚大大增加了肿瘤中肿瘤浸润淋巴细胞的数量
5. Tumor Infiltrating Lymphocyte Therapy for Renal Cell Carcinoma: Methods for ex vivo Expansion and T-Cell Memory Induction [D] . Braun, Mitchell W. 2021

机译：肾细胞癌患者肿瘤浸润淋巴细胞治疗：用于脱型膨胀和T细胞记忆诱导的方法
6. Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity [O] . Jessica Chacon, Shari Pilon-Thomas, Amod Sarnaik, 2013

机译：在黑色素瘤肿瘤扩散肿瘤浸润淋巴细胞（TIL）的起始过程中立即触发4-1BB共刺激会加速CD8 + T细胞的生长和肿瘤特异性
7. Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity [O] . 2013

机译：在黑色素瘤肿瘤中开始浸润淋巴细胞（TIL）扩展的过程中立即触发4-1BB共刺激会加速CD8 + T细胞的生长和肿瘤特异性

Immediate triggering of 4-1BB co-stimulation during initiation of tumor-infiltrating lymphocyte (TIL) expansion from melanoma tumors accelerates CD8+ T-cell outgrowth and tumor specificity

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