Design, Synthesis and Biological Activity of Some Benzimidazoles Derivatives 3-Chloro-4-(Substituted--phenyl-1-(4-{1-[2'-(2H-tetrazol-5-yl)-biphenyl-4- ylmethyl]-1H-benzimidazol-2yl}-phenyl)-azetidin-2-ones

摘要

A novel method for the synthesis of novel 3-Chloro-4(4-chloro-phenyl-1-(4-{1-[2'-(2H-tetrazol- 5-yl)-biphenyl-4-ylmethyl]-1H-benzimidazol-2yl}-phenyl)-azetidin-2-one derivatives have been reported. Structures of all the synthesized compounds have been corroborated on the basis of elemental IR, 1H NMR, 13C NMR and Mass spectro-analytical data. Many Schiff bases were prepared by condensation reaction of nitro compound containing biphenyl tetrazole with aromatic aryl aldehydes derivatives with azetidin-2-one. The synthesized compounds were screened for AT1 Angiotension (A II) Receptor Antagonist activity. The nitro, chlorine, hydroxy, florine, iodo compound containing biphenyl tetrazole Schiff bases azetidin-2-one shows good activity compared with losartan and Telmisartan.