Mycobacterial CYP121 as a target for anti-TB drug discovery

Hend A. A. Abd El-wahab; Ahmed S. Aboraia; Hamdy M. Abdel-Rahman; Mahmoud A. El-Gendy; Claire Simons

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Mycobacterial CYP121 as a target for anti-TB drug discovery

机译：分枝杆菌CYP121作为抗结核药物发现的靶标

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Despite the introduction of the first line treatment regimen forty years ago and the continuous trials since that time to introduce new regimens, tuberculosis (TB) is considered to be the cause of considerable mortality worldwide. Recent research highlighted the Mycobacterium tuberculosis (Mtb)CYP450s as potential drug targets. This article reviews mycobacterial CYP121 as a target for anti-TB drug discovery.

机译：尽管四十年前引入了第一线治疗方案，并且自那时以来进行了连续试验以引入新方案，但结核病（TB）被认为是导致世界范围内大量死亡的原因。最近的研究强调结核分枝杆菌（Mtb）CYP450s作为潜在的药物靶标。本文评论分枝杆菌CYP121作为抗结核药物发现的靶标。

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《Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry》 |2016年第6期|共10页
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Hend A. A. Abd El-wahab; Ahmed S. Aboraia; Hamdy M. Abdel-Rahman; Mahmoud A. El-Gendy; Claire Simons;
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1. Mycobacterial CYP121 as a target for anti-TB drug discovery [J] . Hend A. A. Abd El-wahab, Ahmed S. Aboraia, Hamdy M. Abdel-Rahman, Der Pharma Chemica: journal for medicinal chemistry, pharmaceutical chemistry and computational chemistry . 2016,第6期

机译：分枝杆菌CYP121作为抗结核药物发现的靶标
2. In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery [J] . Kumar M., Vijayakrishnan R., Subba Rao G. Molecular diversity . 2010,第3期

机译：基于计算机模拟的结核分枝杆菌二氢叶酸还原酶的新型有效和选择性小肽抑制剂类别的设计，这是抗结核药物发现的潜在目标
3. The assessment of changes to the nontuberculous mycobacterial metabolome in response to anti-TB drugs [J] . Drapal Margit, Wheeler Paul R., Fraser Paul D. FEMS Microbiology Letters . 2018,第15期

机译：评估抗结核病药物的非泛细菌性质代谢物的变化
4. Integrated Antibody Drug Discovery: From Drug Targets to Functional Antibody Leads [C] . Bowu Luan, Liusong Yin, Sherry Shao, Protein Engineering Summit. . 2018

机译：综合抗体药物发现：从药物靶向功能抗体引导
5. Discovery and analysis of patterns in molecular networks: Link prediction, network analysis, and applications to novel drug target discovery. [D] . Zhang, Minlu. 2012

机译：在分子网络中发现和分析模式：链接预测，网络分析以及在新型药物靶点发现中的应用。
6. Structure of the mycobacterial ATP synthase Fo rotor ring in complex with the anti-TB drug bedaquiline [O] . Laura Preiss, Julian D. Langer, Özkan Yildiz, 2015

机译：分枝杆菌ATP合酶Fo转子环与抗结核药bedaquiline配合的结构
7. Structure of the mycobacterial ATP synthase F_o rotor ring in complex with the anti-TB drug bedaquiline [O] . Preiss, L., Langer, J., Yildiz, Ö., 2015

机译：与抗结核药物bedaquiline复合的分枝杆菌aTp合成酶F _{o 转子环的结构}

Mycobacterial CYP121 as a target for anti-TB drug discovery

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