MYCOBACTERIAL DISEASE DETECTION, TREATMENT, AND DRUG DISCOVERY

摘要

PROBLEM TO BE SOLVED: To provide mycobacterial disease detection, treatment, and drug discovery.SOLUTION: Methods for detecting and treating Mycobacterium-related diseases include the steps of: reducing Mycobacterial virulence; reducing RV3133c dimerization; and treating a subject with a Mycobacterial infection using identified compounds. Examples of compounds useful in the treatment of Mycobacterium-related diseases include: N-(4-[(acetylamino)sulfonyl]phenyl)-3-phenylpropanamide; 1-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-(2-imino-3-methyl-2,3-dihydro-1H-benzimidazol-1yl)ethanone hydrochloride; and 1-(1,3-benzoxazol-2-yl)-3-({4-[(2-hydroxyethyl)sulfonyl]phenyl}amino)acrylaldehyde.