Whole-brain three-dimensional imaging for quantification of drug targets and treatment effects in mouse models of neurodegenerative diseases

摘要

Quantitative histopathology in preclinical neuroscience:Altered brain functionality in neurodegenerative diseases,including Parkinson’s disease(PD)and Alzheimer’s disease(AD),involve complex pathological changes and molecular mechanisms which poses a major challenge for development of effective drug treatments.Progressive loss of specific neuron types and projections are hallmarks of PD and AD and proper histological evaluation of relevant disease models therefore requires highly reliable cell detection.