Acid Base Considerations in Stone-Age Farming Sweet Potato Eaters, Modern-Day Sweet Potato Eaters, and High-Protein Consumers

摘要

Net endogenous acid production (NEAP) can be estimated by a primarily anthropometry-dependent organicacid anion (OA) component and the particularly diet-dependent potential renal acid load (PRAL). However, there is evidencethat certain foods may also impact on the OA component. Here, we discuss measurements of urinary 24-h OA excretionobtained in healthy subjects, against the background of relevant literature with a special focus on former PapuanNew Guinea stone-age farmers eating predominantly highland sweet potatoes. Contrary to the reports in Papuans, we observedonly modest increases of 5-12% in 24-h excretion rates of OAs (including the detoxification product of phenolicand benzoic acids, i.e., hippuric acid) in healthy adults consuming commonly available yellow-fleshed sweet potatoes.This and additional results on OA increases after higher protein intakes suggest that a specification of theNEAP=PRAL+OA model for estimating the diet-dependent acid load to the metabolic system might be useful regardingparticular foods and their effects on the OA component.