Anaphylaxis to Glatiramer Acetate

摘要

Glatiramer acetate (Copaxone, Teva Pharma) and interferon beta are the two only disease-modifying therapiesfor multiple sclerosis. Glatiramer acetate is known for frequently simulating mild, anaphylactoid reactions while true, IgEmediatedallergic reactions have been hardly reported so far. Herein, we report two females suffering from multiple sclerosiswho experienced rapidly aggravating hypersensitivity-reactions upon treatment with glatiramer acetate. Patient oneexperienced an asthma attack, patient two an exacerbation of her urticaria and angioedema. An IgE-mediated mechanismcould be demonstrated by a positive intradermal test to a 1:1000 dilution in the first 31-year old and by a positive skinprick test to a 1:10 diluted skin prick test in the second 32-year old second woman.