A validation method of omeprazole was developed by non-aqueous potentiometric titration method from API and dosages. The titration technique has developed with 0.1 N perchloric acid which was standardized by potassium hydrogen phthalate. The precise study was found with % Relative Standard Deviation which is less than one where no of observations were six. The method was observed with linearity and Correlation Coefficient as r2 > 0.9999 for 100 mg of drug substance weight in 20% to 100%. The recovery in percentage of omeprazole was observed with 99.90 to 100.27%. The method has ruggedness in variety of conditions like different batches of reagents and titrators of different manufactures.
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