A Non-aqueous Potentiometric Titration Method for Validation of Imatinib mesylate from Pharmaceutical Dosages

摘要

A simple precise, rapid accurate and sensitive non-aqueous potentiometric titration method was developed for quantitative determination of imatinib mesylate from pharmaceutical dosage form. The titration was carried out using standardized 0.1 N perchloric acid. The proposed method was found to be precise with % RSD <1 (n = 6). The method showed strict linearity (r~2 > 0.999) between 20 % to 100 % of 500 mg of drug substance weight. The percentage recovery of imatinib mesylate in the optimized method was between 100.087 to 100.692 %. The method is also found to be ragged when checked by different analysts and using different lots of reagents and different makes of titrators.