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Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis

机译:火鸡肝脂血症的肝脏中脂肪含量,脂肪酸模式和铁含量

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BackgroundThe so-called “hepatic lipidosis” in turkeys is an acute progressive disease associated with a high mortality rate in a very short time. Dead animals show a massive fatty degeneration of the liver. The cause is still unclear. Previous findings suggest that there may be parallels to human non-alcoholic fatty liver disease. The object of the study was to examine the changes in the fat contents, the fatty acid composition and the iron content in livers of animals, which have died from hepatic lipidosis. MethodsThe conspicuous livers ( n = 85) were collected from 20 flocks where the phenomenon of massive increased animal losses accompanied by marked macroscopically visible pathological liver steatosis suddenly occurred. For comparison and as a reference, livers ( n = 16) of two healthy flocks were taken. Healthy and diseased flocks were fed identical diets concerning official nutrient recommendations and were operating under standardized, comparable conventional conditions. ResultsCompared to livers of healthy animals, in the livers of turkeys died from hepatic lipidosis there were found massively increased fat levels (130 ± 33.2 vs. 324 ± 101 g/kg dry matter-DM). In all fatty livers, different fatty acids concentrations were present in significantly increased concentrations compared to controls (palmitic acid: 104 g/kg DM, +345%; palmitoleic acid: 18.0 g/kg DM, + 570%; oleic acid: 115 g/kg DM, +437%). Fatty acids concentrations relevant for liver metabolism and inflammation were significantly reduced (arachidonic acid: 2.92 g/kg DM, ?66.6%; eicosapentaenoic acid: 0.141 g/kg DM, ?78.3%; docosahexaenoic acid: 0.227 g/kg DM, ?90.4%). The ratio of certain fatty acids to one another between control and case livers changed analogously to liver diseases in humans (e.g.: C18:0/C16:0 – 0.913 against 0.311; C16:1n7/C16:0 – 0.090 against 0.165; C18:1/C18:0 – 0.938 against 4.03). The iron content in the liver tissue also increased massively (271 ± 51.5 vs 712 ± 214 mg/kg DM). ConclusionThe hepatic lipidosis has a massive impact on the lipid content, the lipid composition and the iron content in the liver. The character of the metabolic disorder includes parallels to the non-alcoholic steatohepatitis in humans.
机译:背景技术在土耳其,所谓的“肝脂血症”是一种急性进行性疾病,在很短的时间内死亡率很高。死动物显示出肝脏大量脂肪变性。原因尚不清楚。先前的发现表明,可能与人类非酒精性脂肪肝疾病相似。该研究的目的是检查动物脂肪中脂肪含量,脂肪酸组成和铁含量的变化,这些脂肪已因肝脂血症而死亡。方法从20个鸡群中收集明显的肝脏(n = 85),其中突然出现大量动物损失并伴有明显的肉眼可见的病理性肝脂肪变性的现象。为了进行比较和作为参考,取了两个健康羊群的肝脏(n = 16)。给健康和患病的鸡群饲喂相同的日粮,有关官方推荐的养分,并在标准化,可比的常规条件下运行。结果与健康动物的肝脏相比,在因肝脂血症而死亡的火鸡肝脏中,脂肪含量大量增加(130±33.2 vs. 324±101 g / kg干物质-DM)。在所有脂肪肝中,与对照组相比,不同的脂肪酸浓度均以显着增加的浓度存在(棕榈酸:104 g / kg DM,+ 345%;棕榈油酸:18.0 g / kg DM,+ 570%;油酸:115 g / kg DM,+ 437%)。与肝脏代谢和炎症相关的脂肪酸浓度显着降低(花生四烯酸:2.92 g / kg DM,≤66.6%;二十碳五烯酸:0.141 g / kg DM,≤78.3%;二十二碳六烯酸:0.227 g / kg DM,≤90.4 %)。对照肝和病例肝之间某些脂肪酸的比例与人类肝脏疾病的变化类似(例如:C18:0 / C16:0 – 0.913对0.311; C16:1n7 / C16:0 – 0.090对0.165; C18: 1 / C18:0 – 0.938对4.03)。肝脏组织中的铁含量也大量增加(271±51.5 vs 712±214 mg / kg DM)。结论肝脂血症对肝脏的脂质含量,脂质组成和铁含量有很大影响。代谢性疾病的特征包括与人类非酒精性脂肪性肝炎的相似之处。

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