Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat

T Hattori; T Murase; M Ohtake; T Inoue; H Tsukamoto; M Takatsu; Y Kato; K Hashimoto; T Murohara; K Nagata

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Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat

机译：新型代谢综合征动物模型的特征：DahlS.Z-Leprfa / Leprfa大鼠

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Objective:The DahlS.Z-Leprfa/Leprfa (DS/obese) rat strain was established from a cross between Dahl salt-sensitive rats and Zucker fatty (fa/fa) rats, the latter of which harbor a missense mutation in the leptin receptor gene (Lepr). We examined whether DS/obese rats might be a suitable animal model of metabolic syndrome in humans.

机译：目的：从Dahl盐敏感性大鼠和Zucker脂肪（fa / fa）大鼠杂交后建立DahlS.Z-Leprfa / Leprfa（DS /肥胖）大鼠品系，后者的瘦素受体存在错义突变基因（Lepr）。我们检查了DS /肥胖大鼠是否可能是人类代谢综合征的合适动物模型。

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《Nutrition & Diabetes 》 |2011年第1期| 共6页
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T Hattori; T Murase; M Ohtake; T Inoue; H Tsukamoto; M Takatsu; Y Kato; K Hashimoto; T Murohara; K Nagata;
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中图分类内分泌腺疾病及代谢病 ;
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1. PREMATURE CARDIAC SENESCENCE IN DahlS.Z-Leprfa/Leprfa RATS AS A NEW ANIMAL MODEL OF METABOLIC SYNDROME [J] . KEIJI TAKAHASHI, MIWA TAKATSU, TAKUYA HATTORI, Nagoya journal of medical science . 2014 ,第1a2期

机译：作为新的代谢综合征动物模型的DahlS.Z-Leprfa / Leprfa大鼠早搏心脏感觉
2. Effects of estrogen on cardiovascular injury in ovariectomized female DahlS.Z-Leprfa/Leprfa rats as a new animal model of metabolic syndrome [J] . MuraseT., HattoriT., OhtakeM., Hypertension: An Official Journal of the American Heart Association . 2012 ,第3期

机译：雌激素对去卵巢雌性DahlS.Z-Leprfa / Leprfa大鼠新陈代谢综合征动物模型心血管损伤的影响
3. Effects of Estrogen on Cardiovascular Injury in Ovariectomized Female DahlS.Z-Leprfa/Leprfa Rats as a New Animal Model of Metabolic Syndrome [J] . Tamayo Murase, Takuya Hattori, Masafumi Ohtake, Hypertension: An Official Journal of the American Heart Association . 2012 ,第3期

机译：雌激素对去卵巢雌性DahlS.Z-Leprfa / Leprfa大鼠新陈代谢综合征动物模型心血管损害的影响
4. Effects of telmisartan on arterial vasodilation via protease-activated receptor-2 activation in SHRSP.Z-Leprfa/IzmDmcr rats with metabolic syndrome [C] . Kagota S., Maruyama K., Wakuda H., International Congress on Coronary Artery Disease. . 2013

机译：综外原对SHRSP.Z-Leprfa / IzmdMCR大鼠蛋白酶活化受体-2激活动脉血管血管血管血管血管血管血管血管血管综合征的影响
5. Development and characterization of a novel animal model of diet-induced insulin resistant diabetes and metabolic dyslipidemia: Mechanistic interactions between dietary fructose, fat and cholesterol, and the possible role of liver X receptor in the induction of metabolic syndrome. [D] . Basciano, Heather. 2006

机译：饮食诱导的胰岛素抵抗性糖尿病和代谢性血脂异常的新型动物模型的开发和表征：饮食中的果糖，脂肪和胆固醇之间的机制相互作用，以及肝脏X受体在代谢综合征的诱导中的可能作用。
6. Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat [O] . T Hattori, T Murase, M Ohtake, 2011

机译：新型代谢综合征动物模型的特征：DahlS.Z-Leprfa / Leprfa大鼠
7. Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat [O] . Hattori, T, Murase, T, Ohtake, M, 2011

机译：新型代谢综合征动物模型的特征：DahlS.Z-Leprfa / Leprfa大鼠

Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Leprfa/Leprfa rat

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