The Effects of Yarrow’s (Achillea millefolium) Hydroalcoholic Extract on Blood Proteins in Mice

摘要

Yarrow (Achillea millefolium) means thousands leaves plant and belongs to Asteraceae family. Yarrow is aperennial plant which grows in mountainous regions of Europe, North Africa and East Asia (including NorthIran and Alborz heights). This plant has many health benefits like treating problems of digestive system,respiratory system, cardiovascular system (stimulating blood circulation and lowering blood pressure), andgenital-urinary system. In this study, the effect of Yarrow extract was evaluated on immunity parameters ofblood serum in little female laboratory rats (Balb/C race). At first, samples were divided randomly in fivegroups: three treatment groups, one control group and one placebo group. Each group had eight membersand all groups were kept in similar conditions. Hydroalcoholic extract was prepared in three doses including50,100 and 200 mg/kg and was injected in peritoneum every two days for twenty days. Normal saline wasinjected to placebo group. All measurements were done using protein electrophoresis method. Measuredparameters were albumin amount, α-1 and α-2 globulin, β globulin, gamma globulin, albumin globulin ratio,and total protein. Results showed that the amount of albumin, β globulin and total protein were increased inall three doses. α-2 were decreased in all treatments and α-1 were increased in all three doses but thisincrease was significant for doses 100 and 200 mg. Albumin globulin ratio was increased also in all treatmentsbut it was significant only for 50 mg. Gamma globulin amount was increased in 50 and 100 mg but decreaseda little in 200 mg. Results of this study showed that Yarrow extract caused significant changes in bloodimmune parameters and can affect immune system of body even in absence of antigenic factors.