Neoagarotetraose-modulated gut microbiota and alleviated gut inflammation in antibiotic treatment mice

摘要

This study aimed to explore the effects of neoagarotetraose (NAT) on gut microbiota composition and inflammation after antibiotic treatment. Our results showed that NAT significantly increased the length of colon (P? ?.01) and decreased the ileocecal valve index (P? ?.05), and reduced IFN-γ content (P? ?.01) and downregulated the IFN-γ/IL-4 ratio (P? ?.01), suggesting that NAT mediated the balance of the Th1/Th2 ratio to maintain the immune equilibrium of the intestinal mucosa. Our data showed that NAT prohibited intestinal inflammation by increasing antimicrobial peptides and gut integrity. Furthermore, NAT administration significantly increased the fecal concentration of total short-chain fatty acids. In addition, NAT had the ability to modulate gut microbiota composition and diversity. In our study, significantly increased Bifidobacterium , Lactobacillus and Prevotella were observed in the NAT group (P? ?.01). In summary, all of these results demonstrated that NAT was a potential prebiotic for modulating intestinal microbiota and promoting host health.