EVALUATION AND OPTIMIZATION OF LEPIDIUM SATIVUM SEED MUCILAGE AS BINDER IN TABLET FORMULATION

摘要

Objective: The study elaborates isolation of mucilage from Lepidium sativum seeds and explores it as a tablet binder. Methods: The mucilage from seed was extracted by precipitation of soaked and blended seed in acetone. The mucilage was evaluated for its binding properties in tablets prepared by wet granulation and direct compression method. The prepared tablets were evaluated for hardness, thickness, friability, disintegrating time and in-vitro drug release and compared with established binder like starch, PVP K-30, HPMC, MCC. Results: The results of isolated mucilage from Lepidium sativum seeds as a binder were very promising. The results indicated that mucilage is required in concentration as low as 2% for wet granulation and 4% for direct compression to give equivalent binding effect. Conclusion: Lepidium sativum seed mucilage [LSM] shows promising potential for its application as a binder in the tablet formulation. Low concentration of LSM as binder would also help to reduce cost of formulation.