FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF CARBAMAZEPINE USING NATURAL SUPERDISINTEGRANT PLANTAGO OVATA SEED POWDER AND MUCILAGE

摘要

An. attempt. has. been. made. for. the. development. of. fast. dissolving. tablets. of. the. carbamazepine. by. wet. granulation. method,. using. different.concentrations. of. natural. superdisintegrating. agent.like. plantego.ovata.seed.powder.and.mucilage..The.major.problem.of.this.drug.is.very. low.solubility. in. biological. fluids. and. poor. bioavailability. after. oral. administration.. Prepared. formulations. were. evaluated. for. p recompressional.parameters. such. as. angle. of. repose,. %. compressibility. and. Hausner's.ratio..Tablets.were.subjected.to.post.compressional.analysis.for.the.parameters. such. as. hardness,. friability,. in. vitro. disintegration. time,. wetting. time. and. dissolution. test.. Drug. compatibility. with. excipients. was.checked. by.FTIR. studies..Stability. studies.were.carried. out.as.per.ICH.guidelines.for. three.months.. The.formulations.prepared. with. mucilage. of.plantego.ovata.were.showed.disintegration.time.between.the.ranges.of.84.58.to.24.74.sec.and.drug.release.showed.between.the.ranges.of.14.–.16.min..However.the.formulations.prepared.with.seed.powder.did.not.disintegrate.in.specified.limit.of.time.for.fast.dissolving.tablet.. Among. all.formulations.SM5.showed.99.71.%.drug.release.within.16.min..The.prepared.tablets.were.characterized.by.FTIR.Studies..No.chemical.interaction.between.drug.and.excipient.was.confirmed.by.FTIR.studies..The.stability.study. conducted. as. per. the. ICH. guidelines. and.the.formulations. were.found.to.be.stable..The.results.concluded.that.fast.dissolving.tablets.of.poorly.soluble.drug,.carbamazepine.showing.enhanced.dissolution,.will.lead.to. improved. bioavailability,. improved. effectiveness.and. hence. better.patient. compliance. by.using. natural.superdisintegrant. like. plantego.ovata