HEPATOPROTECTIVE ACTIVITY OF CHENOPODIUM ALBUM LINN.PLANT AGAINST PARACETAMOL-INDUCED HEPATIC INJURY IN RATS

摘要

Fine.powder.of.Chenopodium.album.Linn...leaves.is.dusted.to.ally.irritation.and.leaf.juice.is.used.for.treating.burns..Decoction.of.aerial.parts.mixed.with. alcohol.is.rubbed.on.the. body. affected. part.by. arthritis.and. rheumatism.. The.present. investigation.describes.hepatoprotective. activities.of.dried. whole. plant. of. Chenopodium. album. Linn,. acetone.and.methanol.extracts,.in.ratio.of.(50:50).against.paracetamol. induced. hepatic. injury..Hepatic. injury. was. achieved. by. injecting. 2.5ml/kg. oral. route. of. pracetamol. in. equal. proportion. with. dimethysulfoxide. (DMSO).. Acetone. and.Methanol.extract.at.dose.levels.of.200.and.400.mg/kg.offered.significant. (P<0.001).. Hepatoprotective. . action. by. reducing. the. serum. marker.enzymes.like.serum.glutamate.oxaloacetate.(SGOT),.serum.glutamate.transaminase.(SGPT)..They.also.reduced.the.elevated.level.of.serum.alkaline.phosphatase.(ALP).serum.acid.phosphatase.(ACP).and.serum.bilirubin..Reduced.enzymic.and.nonenzymic.antioxidant.levels.and.elevated. lipid.peroxide.level.were.restored.to.normal.by.administration. of. methanol. and.acetone.extract. of. Chenopodium.album.Linn..Histopathological.studies.further. confirmed. the.hepatoprotective. activity.of. these.extracts.when.compared.with.Paracetamol.treated.control.groups..The.result. obtained.were. compared. with. silymarin. (100mg/kg;. oral),. the. standard. dru g.. In. conclusion. Aetone. and. Methanol. extract. at. (400mg/kg,. oral). showed.significant.p<0.001.hepatoprotective.activity.similar.to.that.standard.drug,.silymarin