BRIEF COMMUNICATION: PREVENTIVE ROLE OF ENDOTHELIN ANTAGONIST ON KIDNEY ISCHEMIA: REPERFUSION INJURY IN MALE AND FEMALE RATS

摘要

Background: Renal ischemia/reperfusion injury (RIRI) is the most common cause of acute kidneyinjury. We tested the protective role of endothelin?1 receptor blocker; bosentan (BOS) in animalmodel of RIRI in two different genders.Methods: Male and female Wistar rats were assigned as sham operated (sham), control group(ischemia), and case group (ischemia+BOS) treated with BOS (50 mg/kg) 2 h before bilateralkidney ischemia induced by clamping renal vessels for 45 min followed by 24 h of renal reperfusion.Results: The RIRI significantly increased the serum levels of blood urea nitrogen and creatininein both genders (P In male rats, the serum levels of malondialdehyde in the ischemia+BOS group were decreasedsignificantly when compared with ischemia group (P Conclusions: BOS can be used in both genders to attenuate kidney ischemia injury possiblydue to its effect in the renal vascular system.