Chlorthalidone is a phthalamide derivative of benzene sulphonamide and is designated as 2- chloro- 5- (1- hydroxy- 3- oxo- 1- isoindolinyl) benzene sulphanilamide. It is white to yellowish crystalline powder. It is practically insoluble in water, slightly soluble in alcohol. In the present study fast disintegrating tablets of chlorthalidone were prepared by adopting vacuum drying technique to study the effect of different subliming agents with various concentrations on disintegrating time. The powder blend was examined for the pre-compressional parameters. Formulations were evaluated for pre-compressional parameters such as angle of repose, % compressibility and Hausner’s ratio. Tablets were subjected to post-compressional analysis for the parameters such as hardness, friability, in-vitro disintegration time, wetting time and dissolution test. Drug compatibility with excipients was checked by FTIR and DSC studies. Stability studies were carried out as per ICH guidelines for three months. The results obtained showed that quantity of camphor, ammonium bicarbonate, menthol, and urea significantly affect the response variables (P> 0.05). The results revealed that tablets prepared by the vacuum drying technique using 40% camphor (C4) significantly enhanced the dissolution rate of drug. Stability studies carried out as per ICH guidelines for three months and results revealed that upon storage disintegration time of tablets decreased significantly (P> 0.05). The results concluded that fast disintegrating tablets of chlorthalidone showing enhanced dissolution rate with increasing the concentrations of subliming agents. Among all the formulations C4, A4 and M4 shows the improved dissolution rate which lead to improved bioavailability and effective therapy by using vacuum drying technique.
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