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Evaluation of hepatoprotective activity of Boerhaavia diffusa against carbon tetrachloride induced liver toxicity in albino rats

机译:白花蛇舌草对四氯化碳诱导的白化病大鼠肝毒性的肝保护作用评价

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Background: Modern allopathic medicine has very little to offer for the treatment of liver disorders in spite of consistent effort for new drug discovery. Hence, this study was conducted to elucidate the hepatoprotective activity of aqueous extract of traditional medicinal plant Boerhaavia diffusa against carbon tetrachloride (CCl4) induced toxicity in male albino rats. Methods: The hepatoprotective effect of the aqueous extracts of B. diffusa was evaluated by biochemical parameters such as serum alanine transferases (ALT), serum asparate transferases (AST), alkaline phosphatase (ALP), total serum bilirubin, and serum protein, and confirmed by histopathology of liver. The toxicant CCl4 was used to induce hepatotoxicity and silymarin were used as control drug. The aqueous extracts of B. diffusa were administered at the doses of 250 mg/kg/day and 500 mg/kg/day orally for 4 days. One-way analysis of variance was used for the statistical analysis of data. A probability value of p Results: Administration of B. diffusa at doses 250 and 500 mg/kg orally demonstrated hepatoprotective activity by preventing the increase of ALT, AST, ALP, and serum bilirubin and also confirmed by histopathology of the liver. The results were comparable to that of silymarin?. Conclusion: The results of this study confirmed the hepatoprotective activity of aqueous extracts of B. diffusa at doses of 250 mg/kg/and 500 mg/kg/against CCl4 induced hepatotoxicity in rats. However, the dose adjustments may be necessary to optimize the similar hepatoprotective efficacy in clinical settings.
机译:背景:尽管一直致力于新药开发,现代同种疗法药物对于治疗肝脏疾病几乎没有什么用。因此,进行了这项研究以阐明传统药用植物白花蛇舌草水提取物对四氯化碳(CCl4)诱导的雄性白化病大鼠毒性的保护作用。方法:通过生物化学参数,如血清丙氨酸转移酶(ALT),血清天冬氨酸转移酶(AST),碱性磷酸酶(ALP),总血清胆红素和血清蛋白,评估白花蛇舌草水提物对肝脏的保护作用,并确认根据肝脏的组织病理学有毒的四氯化碳被用来诱导肝毒性,水飞蓟素被用作对照药物。以250 mg / kg /天和500 mg / kg /天的剂量口服白花芽孢杆菌的水提物,持续4天。方差的单向分析用于数据的统计分析。 p的概率值。结果:以250和500 mg / kg的剂量口服白花蛇舌草可以预防ALT,AST,ALP和血清胆红素的升高,从而具有保肝活性,并且还可以通过肝脏的组织病理学证实。结果与水飞蓟素相当。结论:这项研究的结果证实了250毫克/千克和500毫克/千克/剂量的白花蛇舌草水提物对CCl4诱导的大鼠肝毒性具有保护作用。但是,可能需要调整剂量以优化临床环境中类似的保肝功效。

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