EVALUATION OF MUTAGENIC EFFECT (ANTIMUTAGENIC) OF DALBERGIA LATIFOLIA ON SWISS ALBINO MICE

摘要

Dalbergia latifolia Roxb. (Family: Fabaceae) is a traditional herb, contain latinone and dalcriodain flavonoid having excellence medicinal value8. Thepresentstudy wasdesignedtoevaluatetheanti-mutagenicpotentialofMethanolic extractof Dalbergia latifolia,usingmicronucleus(MN)andchromosomalaberration(CA)assay inmice bonemarrow.Theanti-mutageniceffectofDalbergia latifoliawasassessed usingcyclophosphamideMNformationandCAinmice.Theanimalswerepre-treatedwiththe MethanolicextractofDalbergia latifoliaorallyattwodosesof100, 200mg/kgbody weightforsevendays.InMNandCAtestthetwodosesprovidedprotectionwhengiven24hrs priortoasinglei.padministrationofcyclophosphamide(100mg/kgbodyweight). Theseresults demonstrate thatMethanolic extractofDalbergia latifoliahas got anti-mutagenic potential.