Final Study Report on the Developmental Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AZT$ CAS No. 30516-87-1) and Dapsone (CAS No. 80-08-0) Administered by Gavage to Swiss Albino (CD-1(Trade Name)) Mice on Gestational Days 6 Through 15

摘要

In the present study, timed-mated Swiss albino (CD-1) mice were dosed by gavage with AZT (0, 100, 200, or 400 mg/kg/day) and dapsone (0, 50, 100 or 200 mg/kg/day) alone or in combination on gestational days (gd) 6 through 15. The vehicle was 0.5% aqueous methylcellulose. Total daily doses were administered in two divided doses (morning and afternoon), each with a volume of 10 ml/kg body weight. The oral route corresponds to one of the commonly used routes in human patients. Dose selection was based on previous studies in which CD-1 mice were treated by gavage with AZT alone or dapsone alone or in combination from gd 6 through 15.