“STUDY OF TOTAL CHOLESTEROL (TC), TRIACYLGLYCEROLS (TG), HIGH DENSITY LIPOPROTEIN CHOLESTEROL (HDL-C) IN TYPE II DIABETES MELLITUS.”

摘要

BACKGROUND- There are probably 100 million people in the world with diabetes mellitus and incidences of diabetes are on the rise. Dyslipidaemia is one of the common disorders which is seen in most of the diabetes patients, which causes cardio vascular disorders. AIM- The aim of this study is to investigate the total cholesterol (TC), triacylglycerols (TG), high density lipoprotein cholesterol (HDL-C) in Type II Diabetes Mellitus and healthy controls. MATERIALS & METHODS: - The study was conducted on 50 control and 50 type II diabetic subject between age group of 30-60 yrs. Serum total cholesterol was determined by an enzymatic (CHOD-PAP) colorimetric method and triglycerides were determined by an enzymatic (GPO-PAP) method & HDL-Cholesterol was estimated by a precipitant method. Statistical analysis was done using Unpaired t-test . RESULTS: The mean value of total cholesterol, triglycerides & HDL-C in normal subjects is 165.5 mg/dl (SD ± 24.24), 118.7 mg/dl (SD ± 41.58), 28.38 mg/dl (SD ± 7.85) and the value of total cholesterol, triglycerides & HDL-C in diabetic patients is 179 mg/dl (SD ± 31.69), 164.35mg/dl (SD ± 27.93), 25.4mg/dl (SD ± 6.86). The observed difference in the means of total cholesterol, triglycerides & HDL-C in normal and diabetic are statistically significant (P<0.05). CONCLUSION: From present study it is concluded that total cholesterol, triglycerides and a HDL cholesterol levels for all persons with type 2 DM should be done as a routine test. Also early diagnosis and treatment of dyslipideamia can be used as a preventive measure for the development of cardiovascular disease in type 2 diabetes KEY WORDS: Diabetes mellitus, Dyslipidaemia, Lipid profile, Total cholesterol, Triglycerides, HDL-C.