Changes of Vascular Wall and Total Cholesterol, High Density Lipoprotein, Oxidized low Density Lipoprotein, Nitric Monoxide and Lipide Peroxidation in Serum after Arcuate Nucleus Lesioned

摘要

After arcuate nucleus of hypothalamus lesioned with monosodium glutamate, changes of vascular wall and total cholesterol, high density lipoprotein, oxidized low density lipoprotein, nitric monoxide and lipid peroxidation in serum were investigated to explore the effect of hypothalamic arcuate nucleus on the development of atherosclerosis. In experimental group of arcuate nucleus lesioned, degeneration of endothelial cells and edematous nuclei of endothelium can be observed, vesicles of various sizes in subendothelial tissue and smooth muscle cells migrated from tunica media to tunica intima through ruptured elastic interna, and the levels of total cholesterol, oxidized low density lipoprotein and lipid peroxidation in serum was significant higher and nitric monoxide was lower than that of control subjects. After cutting infundibulum, degeneration of endothelial cells with edematous nucleus and proliferous collagenous fibers around ruptured myo- endothelial junction were also observed. The structure of control group remained intact. Results suggest that hypothalamic arcuate nucleus might be of significance regulative effect in the development of atherosclerosis.