A comparison of tumor progression in patients with simultaneous prostate cancer and prostate premalignant condition to patients with prostate cancer alone

摘要

Introduction. An evaluation of prostate cancer progressionin group 1 (n – 30) with simultaneous prostate cancer(PCa) and premalignant lesions (PL) in comparisonwith group 2 (n – 159) with prostate cancer alone wascarried out.Materials and methods. All patients underwent radicalprostatectomy (RP). The assessment consisted of PSAlevels, Gleason score (Gs), clinical staging, percentage ofmultifocal tumors, and tumor volume in both groups.Postoperative follow-up was evaluated: including clinicalrecurrence and biochemical recurrence (BCR) rate,metastases, and cancer specific deaths.Results. Sixty percent of patients in group 1 hadclinically insignificant prostate cancer. Although in thisgroup PSA levels, Gs, and tumor staging were statisticallylower. Tumor progression was similar to group 2.A considerably prevalent presence of multifocal tumorsin group 1 did not result in their greater volume