A Double-Blind, Active-Controlled Clinical Trial of Sodium Bicarbonate and Calcium Gluconate in the Treatment of Bilateral Osteoarthritis of the Knee

摘要

Objective:To evaluate the effect of intra-articular injections of sodium bicarbonate with a single (SBCG1) or double dose (SBCG2) of calcium gluconate administered monthly compared with methylprednisolone (MP) for treatment of knee osteoarthritis.Methods:A 3-month, randomized, double-blind clinical trial with patients diagnosed with knee osteoarthritis (OA). The outcome variables were the Western Ontario-McMaster University Osteoarthritis Index (WOMAC) and the Lequesne functional index.Results:After 3?months, all treatments significantly improved in overall WOMAC and Lequesne scores. Mean changes (95% confidence interval) in WOMAC total score and the Lequesne index, respectively, for SBCG1 (?12.5 [?14.3, ?10.7]; ?9.0 [?11.4, ?6.7]) and SBCG2 (?12.3 [?14.3, ?10.4]; ?8.9 [?10.4, ?7.4]) were significantly greater than for MP (?5.0 [?7.2, ?2.8]; ?3.2 [?4.9, ?1.5]) (P?