The effects of specific antibody fragments on the 'irreversible' neurotoxicity induced by Brown snake (Pseudonaja) venom

摘要

1. Brown snake (Pseudonaja) venom has been reported to produce 'ireversible' post synaptic neurotoxicity (Harris & Maltin, 1981; Barnett et al., 1980) 2. A murine phrenic nerve/diaphragm preparation was used to study the neurotoxic efects of this venom and pre-and post-synaptic components were distinguished by varying the temperature and frequency of nerve stimulation. There were no myotoxic effects and the neurotoxicity proved irreversible by washing alone.