A process for isolating and purifying vasopeptidase-inhibiting peptides with specificity for the angiotensin-converting enzyme carboxylic site secreted by snake venom glands (bpps), particularly jararaca bothrops, or endogenously produced (evasins) having vasodilatory and anti- hypertensive; process of determining the starch sequence of inhibitor peptides secreted by the snake venom (bpps) or endogenous (evasin) venom; The process of determining the amino acid sequence of bpps by deducting the cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca. process of determining the amino acid sequence of evasins by deducing cdna from precursors of these molecules expressed in snake tissues, specifically bothrops jararaca, process of amplifying cdna from pancreatic and / or snake brain cdna libraries, specifically bothrops jararaca ; solid phase synthesis process of vasopeptidase inhibiting peptides with vasodilating and antihypertensive action, vaso

摘要

"PROCESS FOR INSULATING AND PURIFYING VASOPEPTIDASE INHIBITOR PEPTIDES, SPECIFIC TO THE CARBOXYLIC SITE OF ANGIOTENSIN CONVERTERING, BRODUCED BY THE VENOUS-SUGARS VENOSPHERE VENOSPHERE VENOSPHERE POISTS Process of determining the amino acid sequence of the inhibitor peptides secreted by the venom glands (BPPs) or the endogenous sequestration of the sinus sequestering SNAPS, SPECIFICALLY BOTHROPS JARARACA, PROCESS OF DETERMINING THE EVASINS AMINO ACIDS SEQUENCE BY DEDUCING THE CDNA OF THE PRECURSORS OF THESE SNAPS / SPECIFICALLY BOTH OF THE CDOTNATE OF THE SNAPSHOT Brain SNAKES, ESPECIALLY BOTHROPS JARARACA; SOLID PHASE SYNTHESIS PROCESS OF VASODILATING AND ANTIHYPERTENSIVE VASOPYDASE INHIBITORY PEPTIDES, ANTIHYPERTENSIVE VASOPEPDASE INHIBITORS; USE OF VASOPEPTIDASE INHIBITOR PEPTIDES WITH VASODILATING AND ANTIHYPERTENSIVE ACTION TO OBTAIN PHARMACEUTICAL COMPOSITIONS; PROCESS OF DETERMINING INHIBITORY ACTIVITY ON VASOPEPTIDASES AND BIOLOGICAL ACTIVITY ON SMOOTH MUSCLE, CARDIOVASCULAR SYSTEM AND MICROCIRCULATORY ". The present invention relates to the isolation of peptides secreted by the snake-venom peptide Bothropsar venom; as well as the process of producing it by genetic engineering techniques in prokaryotic and eukaryotic systems, the engineered peptide thus obtained, the production of said peptide via chemical synthesis as well as the resulting peptide from such chemical processing. said peptides obtained by different processes in different pharmaceutical compositions and introduced into the body by various routes to act as inhibitors of vasopeptidases and consequently reducing systemic blood pressure and local vasodilating action.