Comparison of Anticoagulant Effects of Regulatory Proline-Containing Oligopeptides. Specificity of Glyprolines, Semax, and Selank and Potential for Their Practical Application

摘要

Experimental and theoretical demonstrations of different effect of certain regulatory peptides (RPs) on blood coagulation are available. The problem of the role of RPs in hemostatic processes becomes particularly significant since, first, the peptides are widespread in nature both in animal and plant tissues, second, there is a relationship between the peptide structure and function and, third, both natural and synthetic peptides are used in practical medicine to correct functions of some factors of the hemostatic system. Many peptide inhibitors of the primary and plasma hemostasis potentiating anticoagulant effects in the body have been described.