Surface Modification Of Biphasic Calcium Phosphate Bioceramic Powders

摘要

Biphasic calcium phosphate (BCP)/poly L-lactide (PLLA) biocomposite is proven to be a promising bone graft material or scaffold for bone tissue engineering. To improve the interfacial compatibility of BCP bioceramic with biopolymer-PLLA, BCP powders were surface-modified in different condition to graft polymer groups onto the surface of the BCP powders. L-lactide and L-lactic acid (LA) oligomer were used to modify the BCP surface with stannous octanoate (Sn(0ct)_2) and stannous chloride (SnCl_2) as catalyst, respectively. Results show that the surface modification effect is obvious and the amount of grafted organic group is above 6.5 wt.%. Sn(Oct)_2 and SnCl_2 are the optimal catalysts for the surface grafting reaction of L-lactide and l-LA oligomer, respectively. The surface grafting slightly increase the particle size of BCP powders and reduce the tendency for their agglomeration.