The influence of different culture microenvironments on the generation of dendritic cells from non-small-cell lung cancer patients

摘要

Introduction:Monocyte-derived dendritic cells (DCs) are currently under extensive evaluation as cell vaccines for cancer treatment. Many protocols regarding DCs generation in vitro with different protein components, especially autologous proteins, have been described. On the other hand, active tumor-derived factors in patients-serum could impair monocytes, which might result in their abrogated differentiation into DCs in vitro.