METHOD FOR PREDICTION OF RISK OF HEMATOGENOUS METASTASES IN NON-SMALL-CELL LUNG CANCER PATIENTS AFTER OPERATION

摘要

FIELD: medicine; oncology.;SUBSTANCE: invention can be used to determine the risk of developing hematogenic metastasis in the patients with non-small cell lung cancer (NSCLC) after the radical surgical treatment. Method involves determining the expression level of genes in tumor tissue and histologically unchanged lung tissue using specific primers for mRNA of five actin-binding proteins (ACP): cyclase-associated protein adenylate 1, cofilin 1, profilin 1, fascin 1 and ezrin, then performing a comparative analysis of the level of mRNA expression coding genes of the five listed actin-binding proteins in the tumor tissue relative to the histologically unchanged lung tissue, wherein the increase in the mRNA expression level of each ACS in the tumor tissue as compared to the unchanged patient is evaluated as 1 point, and the total score of 3 to 5 shows an increased risk of developing hematogenous metastases.;EFFECT: use of the invention enables higher accuracy, information value of metastatic disease risk prediction, reduced analysis time.;1 cl, 4 tbl, 3 ex