Phase I and pharmacokinetic study of TSU-68 a novel multiple receptor tyrosine kinase inhibitor by twice daily oral administration between meals in patients with advanced solid tumors

摘要

PurposeA single-agent dose-escalating phase I and pharmacokinetic study on TSU-68, a novel multiple receptor tyrosine kinase inhibitor, was performed to determine the safety profile, maximum-tolerated dose for Japanese patients with advanced solid tumors and to define the recommended dose of phase II studies.