Cyclopentadpyrimidines and substituted cyclopentadpyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin inhibitors, and pyrrolopyrimidines as targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibitor and antitumor agents

摘要

The present invention provides a compound of Formula III, and salts thereof, and a pharmaceutical composition comprising a compound of Formula III:; wherein R1 is selected from the group consisting of:; whereinR2 is H or an alkyl group having from one to ten carbon atoms; R3 is H or an alkyl group having from one to ten carbon atoms; and R4 is H or an alkyl group having from one to ten carbon atoms. Methods of treating a patient with cancer with these compounds are also provided.