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The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro2,3-dpyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents

机译：构象限制的4-取代的-2,6-二甲基呋喃2,3-D嘧啶的设计，合成和生物学评价为多目标受体酪氨酸激酶和微管抑制剂作为潜在的抗肿瘤剂

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Xin Zhang; Sudhir Raghavan; Michael Ihnat; Ernest Hamel; Cynthia Zammiello; Anja Bastian; Susan L. Mooberry; Aleem Gangjee;
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1. The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro[2,3-d]pyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents [J] . Zhang Xin, Raghavan Sudhir, Ihnat Michael, Bioorganic and medicinal chemistry . 2015,第10期

机译：构象受限的4-取代-2,6-二甲基呋喃[2,3-d]嘧啶作为多靶点受体酪氨酸激酶和微管抑制剂作为潜在抗肿瘤剂的设计，合成及生物学评价
2. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2, 3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents [J] . ZhangX., RaghavanS., IhnatM., Bioorganic and medicinal chemistry . 2014,第14期

机译：水溶性4-取代-2,6-二甲基呋喃[2,3-D]嘧啶的设计和发现为多次要受体酪氨酸激酶抑制剂和靶向抗肿瘤剂的微管
3. The design and discovery of water soluble 4-substituted-2,6-dimethylfuro[2, 3-d]pyrimidines as multitargeted receptor tyrosine kinase inhibitors and microtubule targeting antitumor agents [J] . ZhangX., RaghavanS., IhnatM., Bioorganic and medicinal chemistry . 2014,第14期

机译：水溶性4-取代-2,6-二甲基呋喃并[2,3-d]嘧啶类多靶受体酪氨酸激酶抑制剂和微管靶向抗肿瘤药的设计与发现
4. Pyrrolo2,3-dpyrimidine and Pyrazolo3,4-dpyrimidine Derivatives as Selective Inhibitors of the EGF Receptor Tyrosine Kinase [C] . G. Caravatti, J. Bruggen, E. Buchdunger, American Chemical Society . 2001

机译：Pyrrolo 2,3-D嘧啶和吡唑3,4-D嘧啶衍生物作为EGF受体酪氨酸激酶的选择性抑制剂
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. The Design Synthesis and Biological Evaluation of Conformationally Restricted 4-Substituted-26-dimethylfuro23-dpyrimidines as Multi-targeted Receptor Tyrosine Kinase and Microtubule Inhibitors as Potential Antitumor Agents [O] . Xin Zhang, Sudhir Raghavan, Michael Ihnat, -1

机译：构象受限的4-取代的26-二甲基呋喃23-d嘧啶类多靶点受体酪氨酸激酶和微管抑制剂作为潜在抗肿瘤剂的设计合成及生物学评价
7. Dual Inhibitors of Thymidylate Synthase and Dihydrofolate Reductase as Antitumor Agents: Design, Synthesis, and Biological Evaluation of Classical and Nonclassical Pyrrolo2, 3-dpyrimidine Antifolates [O] . -1

机译：胸苷合酶和二氢酚酸还原酶的双抑制剂作为抗肿瘤剂：古典和非生物吡咯的设计，合成和生物学评价2,3-D嘧啶防雾
8. Egf Receptor Mabs and Chemotherapy/Characterization of Synergistic Interactions Between Cyrotoxic Agents and Inhibitors of the Tyrosine Kinase Growth Factor Receptor Signaling Cascade [R] . Seidman, A. 1999

机译：Egf受体单克隆抗体和化学疗法/ Cyrotoxic剂与酪氨酸激酶生长因子受体信号级联抑制剂之间协同相互作用的表征

The design, synthesis and biological evaluation of conformationally restricted 4-substituted-2,6-dimethylfuro2,3-dpyrimidines as multi-targeted receptor tyrosine kinase and microtubule inhibitors as potential antitumor agents

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