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Phase III placebo-controlled double-blind randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy

机译：接受多西他赛/环磷酰胺化疗的乳腺癌患者接受培格非司亭治疗的安慰剂对照双盲随机试验以降低发热性中性粒细胞减少的风险

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PurposePegfilgrastim is a pegylated form of filgrastim, a recombinant protein of granulocyte colony-stimulating factor, that is used to reduce the risk of febrile neutropenia (FN). Here, we report the results of a phase III trial of pegfilgrastim in breast cancer patients receiving docetaxel and cyclophosphamide (TC) chemotherapy.

机译：用途Pegfilgrastim是非格司亭的聚乙二醇化形式，是粒细胞集落刺激因子的重组蛋白，可用于降低发热性中性粒细胞减少症（FN）的风险。在这里，我们报告了接受多西紫杉醇和环磷酰胺（TC）化疗的乳腺癌患者中培格非司亭的III期试验结果。

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期刊名称 Springer Open Choice
作者
Yoshimasa Kosaka; Yoshiaki Rai; Norikazu Masuda; Toshimi Takano; Toshiaki Saeki; Seigo Nakamura; Ryutaro Shimazaki; Yoshinori Ito; Yutaka Tokuda; Kazuo Tamura;
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年(卷),期 -1(23),4
年度 -1
页码 1137–1143
总页数 7
原文格式 PDF
正文语种
中图分类外科学;
关键词
Adjuvant therapy Breast cancer Febrile neutropenia Granulocyte colony-stimulating factor (G-CSF) Pegfilgrastim Docetaxel/cyclophosphamide therapy;

机译：辅助治疗;乳腺癌;发热性中性粒细胞减少;粒细胞集落刺激因子（G-CSF）;培格非司亭;多西他赛/环磷酰胺治疗;

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专利

1. Phase III placebo-controlled, double-blind, randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy [J] . Kosaka Yoshimasa, Rai Yoshiaki, Masuda Norikazu, Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer . 2015,第4期

机译：接受多西紫杉醇/环磷酰胺化疗的乳腺癌患者接受培格非司亭的安慰剂对照双盲随机试验，以降低发热性中性粒细胞减少的风险
2. A Comparison of Proposed Biosimilar LA-EP2006 and Reference Pegfilgrastim for the Prevention of Neutropenia in Patients With Early-Stage Breast Cancer Receiving Myelosuppressive Adjuvant or Neoadjuvant Chemotherapy: Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2), a Phase III, Randomized, Double-Blind Trial [J] . Blackwell Kimberly, Donskih Roman, Jones C. Michael, The oncologist . 2016,第7期

机译：拟议的生物仿制药LA-EP2006与参考培格非司亭预防早期乳腺癌接受骨髓抑制辅助或新辅助化疗的中性粒细胞减少症的比较：培格非司亭随机肿瘤治疗（支持治疗）以评估比较治疗（PROTECT-2），a第三阶段，随机双盲试验
3. A Comparison of Proposed Biosimilar LA-EP2006 and Reference Pegfilgrastim for the Prevention of Neutropenia in Patients With Early-Stage Breast Cancer Receiving Myelosuppressive Adjuvant or Neoadjuvant Chemotherapy: Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2), a Phase III, Randomized, Double-Blind Trial [J] . Kimberly Blackwell, Roman Donskih, C. Michael Jones, The oncologist . 2016,第7期

机译：拟议的生物仿制药LA-EP2006与参考培格非司亭用于预防早期接受骨髓抑制或新辅助化疗的乳腺癌中性粒细胞减少症的比较：培格非司亭随机肿瘤治疗（支持治疗）以评估比较治疗（PROTECT-2），a第三阶段，随机双盲试验
4. Use of Laser Photomodulation in the Evolution of Oral Mucositis Associated to Cyclophosphamide, Methotrexate, 5-Fluouracil - CMF in 5 Fluouracil + Adriamycin + Cyclophosphamide - FAC Chemotherapy Protocols in Patients with Breast Cancer [C] . Maria de Fatima Lima Ferreira, Fabiola Bastos de Carvalho, Susana C. P. S. de Oliveira, Mechanisms for low-light therapy VIII . 2013

机译：激光光调节在5种氟尿嘧啶+阿霉素+环磷酰胺-FAC化疗方案中与环磷酰胺，甲氨蝶呤，5-氟尿嘧啶-CMF相关的口腔黏膜演变中的应用
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. A Comparison of Proposed Biosimilar LA-EP2006 and Reference Pegfilgrastim for the Prevention of Neutropenia in Patients With Early-Stage Breast Cancer Receiving Myelosuppressive Adjuvant or Neoadjuvant Chemotherapy: Pegfilgrastim Randomized Oncology (Supportive Care) Trial to Evaluate Comparative Treatment (PROTECT-2) a Phase III Randomized Double-Blind Trial [O] . Kimberly Blackwell, Roman Donskih, C. Michael Jones, 2016

机译：拟议的生物仿制药LA-EP2006与参考培格非司亭预防早期乳腺癌接受骨髓抑制辅助或新辅助化疗的中性粒细胞减少症的比较：培格非司亭随机肿瘤治疗（支持治疗）以评估比较治疗（PROTECT-2）a第三阶段随机双盲试验
7. Phase III placebo-controlled, double-blind, randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy [O] . 2015

机译：接受多西他赛/环磷酰胺化疗的乳腺癌患者接受培格非司亭治疗的安慰剂对照双盲随机试验，以降低发热性中性粒细胞减少的风险
8. Randomized Trial of Neuroprotective Effects of Erythropoietin in Patients Receiving Adjuvant Chemotherapy for Breast Cancer: Positron Emission Tomography and Neuropsychological Study [R] . Abraham, J. 2008

机译：促红细胞生成素对接受乳腺癌辅助化疗的患者的神经保护作用的随机试验：正电子发射断层扫描和神经心理学研究

Phase III placebo-controlled double-blind randomized trial of pegfilgrastim to reduce the risk of febrile neutropenia in breast cancer patients receiving docetaxel/cyclophosphamide chemotherapy

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