Heterochromatin usually is sequestered near the periphery and the nucleoli in mammalian nuclei. However, in terminally differentiated retinal rod cells of nocturnal mammals, heterochromatin instead accumulates in the interior, to give a so-called inside-out nuclear architecture. Solovei et al. now reports that in most cells, the lamin B receptor mediates peripheral localization early during development and that lamin A/C then takes over this tethering function during terminal differentiation. Furthermore, they show that the unique architecture of the nocturnal animal rod cell is caused by the absence of both tethers and can be phenocopied in LBR/lamin A/C double knockouts.
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机译：异染色质通常隔离在哺乳动物核的外围和核仁附近。但是，在夜间哺乳动物的终末分化视网膜视杆细胞中，异染色质反而在内部积聚，形成所谓的“由内而外”的核结构。 Solovei等。现在报道，在大多数细胞中，lamin B受体在发育早期就介导外周定位，lamin A / C随后在终末分化过程中接管了这种束缚功能。此外，他们表明，夜间动物杆状细胞的独特结构是由两个系链的缺失引起的，并且可以在LBR / lamin A / C双敲除中进行表型复制。
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