Genetic and epigenetic characterization of the tumors in a patient with a tongue primary tumor a recurrence and a pharyngoesophageal second primary tumor

摘要

BackgroundThe choice of therapeutic modality for oral carcinoma in recurrent or second primary tumors remains controversial, as the treatment modalities available might be reduced by the treatment of the first tumor, and the overall survival is lower when compared with patients with a single or first tumor. Identifying biomarkers that predict the risk of relapse and the response to treatment is an emerging clinical issue.