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APOE Genotype Differentially Modulates Effects of Anti-Aβ Passive Immunization in APP Transgenic Mice

机译：APOE基因型差异调节APP转基因小鼠抗Aβ被动免疫的作用。

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摘要

Background APOE genotype is the foremost genetic factor modulating β-amyloid (Aβ) deposition and risk of sporadic Alzheimer’s disease (AD). Here we investigated how APOE genotype influences response to anti-Aβ immunotherapy.

机译：背景APOE基因型是调节β-淀粉样蛋白（Aβ）沉积和散发性阿尔茨海默氏病（AD）风险的首要遗传因素。在这里，我们研究了APOE基因型如何影响对抗Aβ免疫疗法的反应。

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期刊名称 Molecular Neurodegeneration
作者
Joanna E Pankiewicz; Jairo Baquero-Buitrago; Sandrine Sanchez; Jennifer Lopez-Contreras; Jungsu Kim; Patrick M. Sullivan; David M. Holtzman; Martin J. Sadowski;
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作者单位

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年(卷),期 2017(12),-1
年度 2017
页码 12
总页数 17
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Alzheimer’s disease Apolipoprotein E β-amyloid Brain hemorrhages Microglia Neurodegeneration Therapy Vasculopathy;

机译：阿尔茨海默氏病;载脂蛋白E;β-淀粉样蛋白;脑出血;小胶质细胞;神经退行性疾病;治疗;血管病;

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专利

1. APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice [J] . Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, Molecular neurodegeneration . 2017,第1期

机译：APOE基因型差异调节APP转基因小鼠抗Aβ，被动免疫的作用。
2. Differential effects of apoE and apoJ mimetic peptides on the action of an anti-Aβ scFv in 3xTg-AD mice [J] . Laia Montoliu-Gaya, Jofre Güell-Bosch, Gisela Esquerda-Canals, Biochemical Pharmacology . 2018,第期

机译：Apoe和Apoj肽对3XTG-AD小鼠抗AβSCFV作用的差异影响
3. Active immunization with the peptide epitope vaccine A beta 3-10-KLH induces a Th2-polarized anti-A beta antibody response and decreases amyloid plaques in APP/PS1 transgenic mice [J] . Ding Li, Meng Yuan, Zhang Hui-Yi, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2016,第Null期

机译：肽表位疫苗A beta 3-10-KLH的主动免疫可诱导Th2极化的抗A beta抗体反应并减少APP / PS1转基因小鼠的淀粉样斑块
4. Effects of bile acids and derivatives on blood lipid level of ApoE single-knockout mice [C] . Hao Yu, Jinfan Wang, Tong Shu, 2011 International Conference on Remote Sensing, Environment and Transportation Engineering . 2011

机译：胆汁酸及其衍生物对ApoE单敲除小鼠血脂水平的影响
5. Effects of APOE Genotypes and Resveratrol Supplementation on Gut Microbiota Composition and Measures of Nutritional & Inflammatory Status in Mice [D] . Alsayegh, Abdulrahman 2019

机译：APOE基因型和白藜芦醇补充对小鼠肠道菌群组成的影响以及营养和炎症状态的测定
6. APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-β42 in APOE Knock-in and Knock-out Mice [O] . Matthew J. Sharman, Michael Morici, Eugene Hone, -1

机译：ApoE基因型导致对Apoe敲入和敲除小鼠的淀粉样蛋白-β42的外周清除的差异影响
7. APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice [O] . Joanna E Pankiewicz, Jairo Baquero-Buitrago, Sandrine Sanchez, 2017

机译：APOE基因型差异调节APP转基因小鼠抗Aβ，被动免疫的作用。
8. Identification of Novel Therapeutic Targets for Traumatic Brain Injury by Proteomic Analysis of Response to Injury in APOE3 and APOE4 Transgenic Mice [R] . Wood, M., Mouzon, B., Reed, J., 2008

机译：通过蛋白质组学分析apOE3和apOE4转基因小鼠损伤反应鉴定创伤性脑损伤的新治疗靶点

APOE Genotype Differentially Modulates Effects of Anti-Aβ Passive Immunization in APP Transgenic Mice

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