Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity

摘要

A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin (>1c), and four previously undescribed chromone derivatives, including pyanochromone (>3b), spirofuranochromone (>4), 7-hydroxy-6-methoxy-4-oxo-3-[(1E)-3-oxobut-1-en-1-yl]-4H-chromene-5-carboxylic acid (>5), a pyranochromone dimer (>6) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin (>1a), 12-methoxycitromycin (>1b), myxotrichin D (>1d), 12-methoxycitromycetin (>1e), anhydrofulvic acid (>2a), myxotrichin C (>2b), penialidin D (>2c), penialidin F (>3a), SPF-3059-30 (>7), GKK1032B (>8) and secalonic acid A (>9), from cultures of the marine sponge- associated fungus Penicillium erubescens KUFA0220. Compounds >1a–>e, >2a, >3a, >4, >7–>9, were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only >8 exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas >9 showed growth inhibition of methicillin-resistant Staphyllococus aureus (MRSA). None of the compounds were active against Gram-negative bacteria tested.