NOVEL COMPOUNDS HAVING CYTOTOXICITY AND ANTIBACTERIAL ACTIVITY WHICH WERE ISOLATED FROM A MARINE-DERIVED FUNGUS PENICILLIUM SP. AND A USAGE THEREOF

摘要

The invention Marine fungi penny chamber ryumsok (Penicillium sp.) Isolated from strain novel polyoxyalkylene originating suited Parr nesil cyclo hexyl senon (polyoxygenated farnesylcyclohexenones) structure compounds and relates to its alcohol derivative, marine fungi penny chamber separated from ryumsok strain field 7-dia setok represented by the following structural formula the purified (1) nyuson a (7-deacetoxyyanuthone a) and to 2,3-alcohol derivative of the compound represented by the structural formula (2), the human 5 species in vitro It denotes a solid tumor cell lines, A549 (Lung cancer), SK-OV-3 (Ovarian cancer), SK-MEL-2 (Skin cancer), XF498 excellent cancer cell toxic activity against (CNS cancer), (Colon cancer) HCT15, also mechi cylinder-resistance (methicillin-resistant), and multidrug-resistant Staphylococcus aureus of (multidrug-resistant) (Staphylococcus aureus ) exhibits a mild antibacterial activity with low toxicity develop cancer or the pharmaceutical use of the antibacterial agent derived from natural products for the Neunghamyeo, a functional food using the above-mentioned effects can also be used in the pharmaceutical industry and food industry, it is a very useful invention.; And and and (1)