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Study on endocrine disruptors levels in raw milk from cow’s farms: Risk assessment

机译:奶牛场原奶中内分泌干扰物水平的研究:风险评估

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摘要

Diet represents the primary route for human exposure to bisphenol A (BPA). As endocrine disruptor (ED), BPA has raised concerns about its adverse effects on human health. Therefore, EFSA recommended a tolerable daily intake (t-TDI) of 4 μg/kg bw/day and the EU Regulation n. 2018/213 fixed a specific migration limit (SML) of 0.05 mg/kg for BPA in food from plastic materials intended to come in contact with food. BPA could be present in milk due to environmental contamination, and also as a result of the migration from contact materials used during milking and storage. Considering the widespread consumption of milk and milk products, the contamination of dairy products is a matter of public health concern. The aim of the study was to investigate the BPA contamination levels of raw cow’s milk from two farms located in Campania region, Italy. The milk samples (n=22), weekly collected from the cooling tank, were analyzed using liquid chromatography with fluorescence detection. In raw milk from both farms, preliminary results showed the occurrence of BPA levels lower than the SML limit, ranging from not detected to 2.34 μg/L. The consumer exposure, calculated considering a hypothetical raw milk consumption and three possible scenarios, was below the t-TDI. Despite the low levels of exposure through milk consumption, low doses can have lasting effects during human development. Thus, new approaches, methods, and plans should be applied to monitor ED contamination, such as BPA and other pollutants, and to assure milk safety.
机译:饮食是人类接触双酚A(BPA)的主要途径。作为内分泌干扰物(ED),BPA引起了人们对其对人体健康的不利影响的担忧。因此,EFSA建议每日耐受摄入量(t-TDI)为4μg/ kg bw /天,并符合欧盟法规n。 2018/213年将食品中双酚A的特定迁移极限(SML)设定为0.05 mg / kg,该限量旨在用于与食品接触的塑料材料中。由于环境污染以及挤奶和储存过程中所用接触材料的迁移,牛奶中可能存在BPA。考虑到奶和奶制品的广泛消费,奶制品的污染是公共卫生问题。这项研究的目的是调查位于意大利坎帕尼亚地区的两个农场的生牛奶中BPA的污染水平。使用具有荧光检测功能的液相色谱分析每周从冷却水箱收集的牛奶样品(n = 22)。在两个农场的原料奶中,初步结果表明,双酚A的含量低于SML限值,范围从未检测到2.34μg/ L。考虑到假设的原奶消费量和三种可能的情况,计算得出的消费者风险低于t-TDI。尽管通过食用牛奶的接触水平很低,但低剂量仍可在人类发育过程中产生持久影响。因此,应采用新的方法,方法和计划来监测ED污染,例如BPA和其他污染物,并确保牛奶安全。

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