Topsensterols A–C Cytotoxic Polyhydroxylated Sterol Derivatives from a Marine Sponge Topsentia sp.

摘要

Three new polyhydroxylated sterol derivatives topsensterols A–C (>1–>3) have been isolated from a marine sponge Topsentia sp. collected from the South China Sea. Their structures were elucidated by detailed analysis of the spectroscopic data, especially the NOESY spectra. Topsensterols A–C (>l–>3) possess novel 2β,3α,4β,6α-tetrahydroxy-14α-methyl Δ⁹⁽¹¹⁾ steroidal nuclei with unusual side chains. Compound >2 exhibited cytotoxicity against human gastric carcinoma cell line SGC-7901 with an IC50 value of 8.0 μM. Compound >3 displayed cytotoxicity against human erythroleukemia cell line K562 with an IC50 value of 6.0 μM.