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Interactions of Aging Overload and Creatine Supplementation in Rat Plantaris Muscle

机译:大鼠足底肌肉的衰老超负荷和肌酸补充的相互作用

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摘要

Attenuation of age-related sarcopenia by creatine supplementation has been equivocal. In this study, plantaris muscles of young (Y; 5m) and aging (A; 24m) Fisher 344 rats underwent four weeks of either control (C), creatine supplementation (Cr), surgical overload (O), or overload plus creatine (OCr). Creatine alone had no effect on muscle fiber cross-sectional area (CSA) or heat shock protein (HSP70) and increased myonuclear domain (MND) only in young rats. Overload increased CSA and HSP70 content in I and IIA fibers, regardless of age, and MND in IIA fibers of YO rats. CSA and MND increased in all fast fibers of YOCr, and CSA increased in I and IIA fibers of AOCr. OCR did not alter HSP70, regardless of age. MND did not change in aging rats, regardless of treatment. These data indicate creatine alone had no significant effect. Creatine with overload produced no additional hypertrophy relative to overload alone and attenuated overload-induced HSP70 expression.
机译:通过补充肌酸来减轻与年龄有关的肌肉减少症是模棱两可的。在这项研究中,年轻(Y; 5m)和衰老(A; 24m)Fisher 344大鼠的足底肌肉接受了四个星期的对照(C),肌酸补充(Cr),手术超负荷(O)或超负荷加肌酸( OCr)。仅肌酸对肌纤维横截面积(CSA)或热休克蛋白(HSP70)没有影响,仅在幼鼠中增加了肌核结构域(MND)。无论年龄如何,超负荷都会增加I和IIA纤维中CSA和HSP70的含量,以及YO大鼠IIA纤维中MND的增加。 CSA和MND在所有YOCr快速纤维中均增加,而CSA在AOCr的I和IIA纤维中均增加。无论年龄如何,OCR都不会改变HSP70。无论采用何种治疗方法,衰老大鼠的MND均未改变。这些数据表明单独的肌酸无明显作用。相对于单独的超负荷,具有超负荷的肌酸不会产生额外的肥大,并且会减弱超负荷诱导的HSP70表达。

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