Factors VIII and Von Willebrand Levels in Women Undergoing Assisted Reproduction: Are Their Levels Associated with Clinical Pregnancy Outcome?

摘要

A growing number of infertile women are considering pregnancy through assisted reproductive technologies (ART). To date, fertility therapy in women undergoing Assisted Reproduction may act as cardiometabolic stress, in particular, by increasing the risk of short and long-term adverse cardiovascular events.1,2 Therefore fertility therapy may represent a sex-specific atherothrombotic risk factor, in particular in women at an advanced age (>40 yrs) undergoing oocyte donation procedures. Hormonal fertility treatment is associated with a procoagulant milieu by increasing coagulation factors, reducing fibrinolysis, and altering rheological parameters;3,4 this status is comparable with that observed in women who conceived spontaneously. It is well known that Assisted Reproduction procedures confer a risk of venous thromboembolism, although the absolute magnitude is quite low.5