Benzo(a)pyrene exposure induced neuronal loss plaque deposition and cognitive decline in APP/PS1 mice

摘要

Scheme of experimental design for in vivo studies. BaP (1 mg/kg/bw/day) or corn oil was administered into 4-month-old WT mice and APP/PS1 transgenic mice (WT-vehicle, WT-BaP, APP/PS1-vehicle, APP/PS1-BaP) for 2 consecutive months. Morris water maze and open field behavior tests were performed one month after the initiation/termination of BaP exposure. Then, the mice were sacrificed for gene expression profiling and histological/biochemical analyses 1 month after 2-month BaP exposure