Stimulation of histamine H4 receptors increases the production of IL‐9 in Th9 polarized cells

摘要

Th9 cells represent a recently defined subset of CD4+ T‐helper cells, characterized by a high production of IL‐9. They are found at increased frequency in lesions of atopic dermatitis, where IL‐9 is also elevated. As histamine is up‐regulated in lesions of inflammatory skin diseases, we investigated the expression profile of histamine receptors and their functional role on Th9 cells.