Lyme disease (LD) has become the most common vector-borne illness in the northern hemisphere. The causative agent, Borrelia burgdorferi sensu lato, is capable of establishing a persistent infection within the host. This is despite the activation of both the innate and adaptive immune responses. B. burgdorferi utilizes several immune evasion tactics ranging from the regulation of surface proteins, tick saliva, antimicrobial peptide resistance, and the disabling of the germinal center. This review aims to cover the various methods by which B. burgdorferi evades detection and destruction by the host immune response, examining both the innate and adaptive responses. By understanding the methods employed by B. burgdorferi to evade the host immune response, we gain a deeper knowledge of B. burgdorferi pathogenesis and Lyme disease, and gain insight into how to create novel, effective treatments.
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机译：莱姆病（LD）已成为北半球最常见的载体传染病。致病因子Borrelia Burgdorferi Sensu Lato能够在主机内建立持续的感染。尽管激活了先天和适应性免疫应答。 B. Burgdorferi利用了几种免疫逃避策略，从调节表面蛋白，蜱唾液，抗微生物肽抗性和发芽中心的禁用。该审查旨在涵盖B.Burgdorferi的各种方法，通过宿主免疫应答，检查先天和适应性反应。通过了解B.Burgdorferi逃避宿主免疫应答的方法，我们深入了解B.Burgdorferi发病机制和莱姆病，并深入了解如何创造新颖，有效治疗。
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